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| Nomenclature |
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Symbol:
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Cdc25ctm1Hpw
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Name:
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cell division cycle 25C;
targeted mutation 1, Helen Piwnica-Worms
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MGI ID: |
MGI:2180791 |
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Synonyms: |
Cdc25C- |
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Gene:
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Cdc25c
Location:
Chr18:34732997-34751533 bp, - strand
Genetic Position: Chr18,
18.71 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69601
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 3 was disrupted by the insertion of a neomycin resistance gene. Northern blot analysis of total testicular RNA showed the exclusive presence of a longer transcript, containing the neo transgene, in extracts from homozygous mutant mice. Western blot analysis of MEF lysates derived from homozygous mutant animals showed an absence of encoded protein using various antibodies. (J:69601)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:69601
Chen MS et al.,
"Absence of apparent phenotype in mice lacking cdc25c protein phosphatase."
Mol Cell Biol 2001 Jun;21(12):3853-61
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All: |
4 reference(s)
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Analysis Tools
