|
|
| Nomenclature |
|
Symbol:
|
Cd59atm1Bpm
|
|
Name:
|
CD59a antigen;
targeted mutation 1, B Paul Morgan
|
|
MGI ID: |
MGI:2180771 |
|
Synonyms: |
CD59-, Cd59a-, mCd59a- |
|
Gene:
|
Cd59a
Location:
Chr2:104095801-104115354 bp, + strand
Genetic Position: Chr2,
54.53 cM, cytoband E2-E4
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:70419
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
129/Sv
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A neomycin selection cassette was inserted to replace exon 3, which encodes the majority of the protein. FACS analysis showed an absence of protein expression on the surface of erythrocytes, leukocytes, and platelets isolated from homozygous mutant mice. The lack of protein expression was confirmed by immunhistochemical analysis in a variety of tissues. (J:70419)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Cd59a Mutation:
|
9 strains or lines available |
|
| References |
|
Original: |
J:70419
Holt DS et al.,
"Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria."
Blood 2001 Jul 15;98(2):442-9
|
|
All: |
21 reference(s)
|
|
Analysis Tools
