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| Nomenclature |
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Symbol:
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Pik3cbtm1Nbm
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Name:
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phosphatidylinositol 3-kinase, catalytic, beta polypeptide;
targeted mutation 1, Robert L Nussbaum
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MGI ID: |
MGI:2180703 |
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Synonyms: |
p110beta-, Pik3cbdel |
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Gene:
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Pik3cb
Location:
Chr9:99038402-99140621 bp, - strand
Genetic Position: Chr9,
51.41 cM, cytoband E4
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Phase contrast microscopy of blastobysts flushed at day 3.5 d.p.c.
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75617
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Two exons spanning nucleotides 2943-3180 were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event deletes 79 amino acids from position 982-1060 forming 28% of the phosphoinositol 3-kinase catalytic domain. (J:75617)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pik3cb Mutation:
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82 strains or lines available |
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| References |
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Original: |
J:75617
Bi L et al.,
"Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase."
Mamm Genome 2002 Mar;13(3):169-72
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All: |
3 reference(s)
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Analysis Tools
