|
|
| Nomenclature |
|
Symbol:
|
Cd22tm1Eac
|
|
Name:
|
CD22 antigen;
targeted mutation 1, Edward A Clark
|
|
MGI ID: |
MGI:2180680 |
|
Synonyms: |
Cd22- |
|
Gene:
|
Cd22
Location:
Chr7:30865404-30880342 bp, - strand
Genetic Position: Chr7,
19.26 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:37451
|
|
Parent Cell Line:
| E14.1a (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Portions of exons 3 and 4 were replaced with a neomycin selection cassette, which introduced stop codons into all three reading frames. The deleted region encoded the translational start site, leader sequence, and the ligand-binding immunoglobulin domain 1. The splice sites on the 5' and 3' terminals of exons 3 and 4, respectively, were left intact. (J:37451)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:37451
Otipoby KL et al.,
"CD22 regulates thymus-independent responses and the lifespan of B cells."
Nature 1996 Dec 19-26;384(6610):634-7
|
|
All: |
7 reference(s)
|
|
Analysis Tools
