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| Nomenclature |
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Symbol:
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Ccr7tm1Rfor
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Name:
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chemokine (C-C motif) receptor 7;
targeted mutation 1, Reinhold Forster
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MGI ID: |
MGI:2180679 |
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Synonyms: |
CCR7- |
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Gene:
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Ccr7
Location:
Chr11:99144196-99155077 bp, - strand
Genetic Position: Chr11,
62.92 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57976
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Parent Cell Line:
| E14K (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: 0.5 kb of exon 3 encoding serine 139 to aspartic acid 309 was disrupted by insertion of a neomycin resistance cassette via homologous recombination. Successful targeting was verified in homozygous mutant animals by Southern blot analysis and chemotaxis assays. Spleen cells from homozygous animals demonstrated lack of chemotactic response towards EBI-1 ligand chemokine (ELC), a known ligand of the targeted gene. (J:57976)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57976
Forster R et al.,
"CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
Cell 1999 Oct 1;99(1):23-33
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All: |
121 reference(s)
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Analysis Tools
