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| Nomenclature |
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Symbol:
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Cav3tm1Mls
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Name:
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caveolin 3;
targeted mutation 1, Michael P Lisanti
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MGI ID: |
MGI:2180558 |
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Synonyms: |
cav-3-, CAV3 - |
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Gene:
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Cav3
Location:
Chr6:112459505-112472872 bp, + strand
Genetic Position: Chr6,
52.26 cM, cytoband E1
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Cav3tm1Mls/Cav3tm1Mls hearts display progressive left ventricular wall thickening
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69965
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Parent Cell Line:
| WW6 (ES Cell) |
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Strain of Origin:
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STOCK 129/Sv and C57BL/6J and SJL
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2, which codes the all of the functional domains, was replaced by a neomycin selection cassette. Protein expression was undetectable via western blot analysis of lysates from skeletal muscle, heart, and lung tissues obtained from homozygous mutant mice. (J:69965)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cav3 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:69965
Galbiati F et al.,
"Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities."
J Biol Chem 2001 Jun 15;276(24):21425-33
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All: |
12 reference(s)
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Analysis Tools
