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| Nomenclature |
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Symbol:
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Dlx5tm1Levi
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Name:
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distal-less homeobox 5;
targeted mutation 1, Giovanni Levi
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MGI ID: |
MGI:2180474 |
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Synonyms: |
Dlx5-lacZ, Dlx5/LacZ |
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Gene:
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Dlx5
Location:
Chr6:6877805-6882085 bp, - strand
Genetic Position: Chr6,
2.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:56557
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector containg a promoterless lacZ gene and a floxed neomycin resistance gene under the control of a RSV promoter was used to delete a region spanning from within exon 1 to the 5' region of exon 3. RT-PCR analysis showed an absence of transcript in total RNA obtained from homozygous mutant embryos. This allele was used to generate a subsequent allele, Dlx5tm1.1Levi, which lacks the neomycin resistance gene. (J:56557)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:56557
Acampora D et al.,
"Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5."
Development 1999 Sep;126(17):3795-809
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All: |
7 reference(s)
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Analysis Tools
