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| Nomenclature |
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Symbol:
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Tfap2btm1Rbu
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Name:
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transcription factor AP-2 beta;
targeted mutation 1, Reinhard Buettner
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MGI ID: |
MGI:2180473 |
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Synonyms: |
AP-2Beta-, Tcfap2btm1Rbu |
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Gene:
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Tfap2b
Location:
Chr1:19208914-19238734 bp, + strand
Genetic Position: Chr1,
6.19 cM, cytoband A2-A4
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Postaxial accessory digits in Tfap2btm1Rbu/Tfap2btm1Rbu mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:42260
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The insertion of a PGK-neo cassette disrupted exon 4, which encodes an essential DNA binding domain. Northern blot and Western blot analyses showed an absence of transcript and protein, respectively, in midbrain lysates obtained from homozygous mutant mice. (J:42260)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tfap2b Mutation:
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1 strain or line available |
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| References |
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Original: |
J:42260
Moser M et al.,
"Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta."
Genes Dev 1997 Aug 1;11(15):1938-48
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All: |
8 reference(s)
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Analysis Tools
