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| Nomenclature |
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Symbol:
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Sim1tm1Fan
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Name:
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single-minded homolog 1 (Drosophila);
targeted mutation 1, Chen-Ming Fan
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MGI ID: |
MGI:2180390 |
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Synonyms: |
Sim- |
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Gene:
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Sim1
Location:
Chr10:50895651-50989152 bp, + strand
Genetic Position: Chr10,
24.87 cM, cytoband B3-B4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50772
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neo cassette was inserted to replace the first 750 nucleotides of the 5' region, the initiation codon, and the first 17 codons of the basic helix-loop-helix (bHLH) domain. While message was present in homozygous mutant mice at levels only slightly below normal, immunocytochemistry analysis showed an absence of protein product in the coronal sections of the brain. (J:50772)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sim1 Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:50772
Michaud JL et al.,
"Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1."
Genes Dev 1998 Oct 15;12(20):3264-75
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All: |
10 reference(s)
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Analysis Tools
