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| Nomenclature |
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Symbol:
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Tbx21tm1Glm
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Name:
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T-box 21;
targeted mutation 1, Laurie H Glimcher
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MGI ID: |
MGI:2180194 |
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Synonyms: |
T-bet-, Tbx21- |
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Gene:
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Tbx21
Location:
Chr11:97098071-97115331 bp, - strand
Genetic Position: Chr11,
60.95 cM, cytoband D
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Phenotype of aortic arch atherosclerotic lesions in Tbx21tm1Glm/Tbx21tm1Glm Ldlrtm1Her/Ldlrtm1Her and Ldlrtm1Her/Ldlrtm1Her mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:73833
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette was used to replace a 2 kb region containing exon 1 and its flanking sequence. An absence of mRNA and protein were observed in T cells isolated from the lymph nodes of homozygous mutant mice by Northern blot and Western blot analysis, respectively. (J:73833, J:96620)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Susceptibility to Spontaneous Ulcerative Colitis (Rag2tm1Fwa Tbx21tm1Glm double homozygotes J:141481)
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| References |
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Original: |
J:73833
Szabo SJ et al.,
"Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells."
Science 2002 Jan 11;295(5553):338-42
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All: |
152 reference(s)
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Analysis Tools
