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| Nomenclature |
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Symbol:
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Sgcdtm1Mcn
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Name:
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sarcoglycan, delta (dystrophin-associated glycoprotein);
targeted mutation 1, Elizabeth M McNally
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MGI ID: |
MGI:2180193 |
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Synonyms: |
dsg-, Scgd- |
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Gene:
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Sgcd
Location:
Chr11:46896253-47988969 bp, - strand
Genetic Position: Chr11,
28.09 cM, cytoband B1.2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76730
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette was used to replace exon 2, which encodes the translation initiation codon and the cytoplasmic and transmembrane domains. Northern analysis showed that message was not transcribed in skeletal muscle of homozygous mutant mice. The lack of protein in immunoblots further confirmed complete inactivation. (J:76730)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:76730
Hack AA et al.,
"Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex."
J Cell Sci 2000 Jul;113(Pt 14):2535-44
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All: |
17 reference(s)
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Analysis Tools
