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| Nomenclature |
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Symbol:
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Aestm1Grid
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Name:
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amino-terminal enhancer of split;
targeted mutation 1, Tom Gridley
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MGI ID: |
MGI:2180116 |
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Synonyms: |
Aes-, Grg5-, Grgdelta1 |
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Gene:
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Aes
Location:
Chr10:81559560-81566364 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29516
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced exon 2 and also introduces both termination and polyadenylation signals into the open reading frame. The authors noted that if the aforementioned signals were not recognized, the splicing of exons 1 and 3 would result in frameshift mutation. Western analysis of lysates isolated from the brains and spleens of homozygous mutant mice showed an absence of protein expression. (J:29516)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aes Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:29516
Mallo M et al.,
"Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex."
Dev Dyn 1995 Nov;204(3):338-47
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All: |
5 reference(s)
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Analysis Tools
