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| Nomenclature |
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Symbol:
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Asic2tm1Wsh
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Name:
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acid-sensing (proton-gated) ion channel 2;
targeted mutation 1, Michael J Welsh
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MGI ID: |
MGI:2180111 |
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Synonyms: |
ASIC2-, BNC1- |
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Gene:
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Asic2
Location:
Chr11:80880169-81968457 bp, - strand
Genetic Position: Chr11,
48.43 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76712
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted to disrupt two exons encoding the second transmembrane domain, which is common to both splice variants, as well as a channel pore. Transcripts were not detected in the brains of homozygous mutant mice. Neither in situ hybridization nor immunostaining detected protein in the large or small dorsal root ganglion neurons of homozygous animals. (J:76712)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:76712
Price MP et al.,
"The mammalian sodium channel BNC1 is required for normal touch sensation."
Nature 2000 Oct 26;407(6807):1007-11
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All: |
17 reference(s)
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Analysis Tools
