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| Nomenclature |
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Symbol:
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Nefltm1Jpj
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Name:
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neurofilament, light polypeptide;
targeted mutation 1, Jean-Pierre Julien
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MGI ID: |
MGI:2180095 |
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Synonyms: |
L-, NF-L-, NFL- |
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Gene:
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Nefl
Location:
Chr14:68083863-68089095 bp, + strand
Genetic Position: Chr14,
35.46 cM, cytoband D3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44421
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 0.7 kb of the gene including exon 1 was replaced with a neomycin resistance cassette by homologous recombination. Northern and Western blots of brain and nervous tissue from homozygous mutant animals did not detect gene expression, nor were any truncated mRNA species or protein fragments detected. (J:44421)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nefl Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:44421
Zhu Q et al.,
"Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments."
Exp Neurol 1997 Nov;148(1):299-316
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All: |
25 reference(s)
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Analysis Tools
