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| Nomenclature |
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Symbol:
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Acp5tm1Ahdm
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Name:
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acid phosphatase 5, tartrate resistant;
targeted mutation 1, Addenbrookes Hospital Department of Medicine
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MGI ID: |
MGI:2180086 |
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Synonyms: |
Acp5-, TRACP-, TRAP- |
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Gene:
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Acp5
Location:
Chr9:22126731-22135746 bp, - strand
Genetic Position: Chr9,
8.38 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36232
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Parent Cell Line:
| CCB (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 2, which encodes the conserved putative iron-binding domain, was disrupted by the insertion of a neomycin resistance gene. Acid phosphatase activity specific to this osteoclast isozyme was assayed and found to be undetectable in bone homogenates from homozygous mutant mice. Further analysis using histochemical staining confirmed the absence of a functional enzyme. (J:36232)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Acp5 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:36232
Hayman AR et al.,
"Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis."
Development 1996 Oct;122(10):3151-62
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All: |
7 reference(s)
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Analysis Tools
