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| Nomenclature |
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Symbol:
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Dnahc5Tg1Htz
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Name:
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dynein, axonemal, heavy chain 5;
transgene insertion 1, Nathaniel Heintz
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MGI ID: |
MGI:2180081 |
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Synonyms: |
Mdnah5 - |
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Gene:
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Dnahc5
Location:
Chr15:28203752-28472045 bp, + strand
Genetic Position: Chr15,
10.9 cM
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA/J)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Insertion |
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Mutation details: This mutation resulted from the random integration of a transgene (not identified in paper). RT-PCR analysis demonstrated that a transcript with the transgene replacing sequences between exons 16 and 22 was expressed, resulting in the generation of a stop codon at the start of the transgene. The predicted translated product of this fusion transcript lacks all of the known functional domains of the protein. (J:76189)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dnahc5 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:76189
Ibanez-Tallon I et al.,
"Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus."
Hum Mol Genet 2002 Mar 15;11(6):715-21
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All: |
2 reference(s)
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Analysis Tools
