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| Nomenclature |
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Symbol:
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Acadltm1Uab
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Name:
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acyl-Coenzyme A dehydrogenase, long-chain;
targeted mutation 1, University of Alabama
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MGI ID: |
MGI:2180079 |
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Synonyms: |
LCAD- |
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Gene:
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Acadl
Location:
Chr1:66830839-66863277 bp, - strand
Genetic Position: Chr1,
33.64 cM
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Histopathology on Acadltm1Uab/Acadl+ and Acadltm1Uab/Acadltm1Uab mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51660
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A gap-repair insertion was used to duplicate exons 3 and 4. Analysis of the mutant cDNA showed a duplication of exons 3 and 4 as well as the excision of the neomycin selection gene and the plasmid sequence. Northern blot analysis demonstrated normal expression levels of mutant transcript. No protein was detected by immunoblots in isolates from liver mitochondria of homozygous mutant animals. (J:51660)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:51660
Kurtz DM et al.,
"Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation."
Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15592-7
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All: |
13 reference(s)
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Analysis Tools
