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| Nomenclature |
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Symbol:
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Actc1tm1Jll
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Name:
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actin, alpha, cardiac muscle 1;
targeted mutation 1, James Lessard
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MGI ID: |
MGI:2180072 |
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Synonyms: |
cardiac alpha-actin- |
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Gene:
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Actc1
Location:
Chr2:114047282-114053548 bp, - strand
Genetic Position: Chr2,
57.55 cM
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Myofibrillar disarray in newborn Actc1tm1Jll/Actc1tm1Jll hearts
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40165
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: A targeting construct containing HPRT was used to disrupt exon 2. A truncated transcript was detected in extracts from the hearts of homozygous mutant mice, but was shown to be non-coding by the lack of either a normal or truncated peptide in Western blots. (J:40165)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Actc1 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:40165
Kumar A et al.,
"Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin."
Proc Natl Acad Sci U S A 1997 Apr 29;94(9):4406-11
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All: |
3 reference(s)
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Analysis Tools
