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| Nomenclature |
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Symbol:
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Zmpste24tm1Lotn
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Name:
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zinc metallopeptidase, STE24;
targeted mutation 1, Carlos Lopez-Otin
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MGI ID: |
MGI:2180033 |
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Gene:
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Zmpste24
Location:
Chr4:121059237-121098241 bp, - strand
Genetic Position: Chr4,
56.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76209
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P2/Ola
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 and 3 were replaced with a promoter-less IRES-beta-geo cassette via homologous recombination. Western blot analysis of kidneys from homozygous mutant animals confirmed absence of gene expression. (J:76209)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Zmpste24 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:76209
Pendas AM et al.,
"Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice."
Nat Genet 2002 May;31(1):94-9
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All: |
8 reference(s)
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Analysis Tools
