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| Nomenclature |
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Symbol:
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Xrcc5tm1Dbr
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Name:
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X-ray repair complementing defective repair in Chinese hamster cells 5;
targeted mutation 1, David B Roth
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MGI ID: |
MGI:2179987 |
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Synonyms: |
Ku80-, Ku86-, xrcc5-, xrcc5M1 |
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Gene:
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Xrcc5
Location:
Chr1:72307421-72394952 bp, + strand
Genetic Position: Chr1,
36.5 cM, cytoband E
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:34834
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 6 kb of this gene encoding amino acids 229-313 were replaced with a PGK-puro cassette via homologous recombination resulting in a frameshift after residue 313 and deleting 69% of the protein product. Northern blot analysis and RT-PCR of embryonic fibroblasts from homozygous mutants did not detect gene transcript. (J:34834)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Xrcc5 Mutation:
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34 strains or lines available |
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| References |
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Original: |
J:34834
Zhu C et al.,
"Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates."
Cell 1996 Aug 9;86(3):379-89
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All: |
21 reference(s)
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Analysis Tools
