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| Nomenclature |
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Symbol:
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Scnn1btm1Wsh
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Name:
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sodium channel, nonvoltage-gated 1 beta;
targeted mutation 1, Michael J Welsh
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MGI ID: |
MGI:2179819 |
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Synonyms: |
betaENaC - |
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Gene:
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Scnn1b
Location:
Chr7:121865111-121918515 bp, + strand
Genetic Position: Chr7,
65.07 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:53058
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the first exon and part of the first intron. RT-PCR analysis on lung and kidney mRNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:53058)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Scnn1b Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:53058
McDonald FJ et al.,
"Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype."
Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1727-31
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All: |
2 reference(s)
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Analysis Tools
