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| Nomenclature |
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Symbol:
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Scn5atm1Agrc
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Name:
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sodium channel, voltage-gated, type V, alpha;
targeted mutation 1, Andrew A Grace
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MGI ID: |
MGI:2179753 |
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Synonyms: |
Scn5a- |
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Gene:
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Scn5a
Location:
Chr9:119483410-119579016 bp, - strand
Genetic Position: Chr9,
71.33 cM
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Morphology of E10.5 control and Scn5atm1Agrc/Scn5atm1Agrc hearts
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76331
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2 was replaced with a splice acceptor (SA)-Gfp-PGK-neo cassette via homologous recombination. RT-PCR analysis verified the lack of gene expression in homozygous mutant animals. (J:76331)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Scn5a Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:76331
Papadatos GA et al.,
"Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a."
Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6210-5
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All: |
8 reference(s)
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Analysis Tools
