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| Nomenclature |
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Symbol:
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Kcnab2tm1Kmc
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Name:
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potassium voltage-gated channel, shaker-related subfamily, beta member 2;
targeted mutation 1, Ken McCormack
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MGI ID: |
MGI:2179738 |
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Synonyms: |
Kvbeta2- |
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Gene:
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Kcnab2
Location:
Chr4:152390742-152477871 bp, - strand
Genetic Position: Chr4,
83.08 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75891
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A PGK-neo cassette was used to disrupt the beta sheet structural element of this gene via homologous recombination resulting in a structurally unstable protein product. Immunofluorescent staining and Western blot analysis of brain lysate from homozygous mutant animals confirmed the absence of protein product. (J:75891)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kcnab2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:75891
McCormack K et al.,
"Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2)."
J Biol Chem 2002 Apr 12;277(15):13219-28
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All: |
3 reference(s)
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Analysis Tools
