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| Nomenclature |
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Symbol:
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Hap1tm1Hay
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Name:
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huntingtin-associated protein 1;
targeted mutation 1, Michael R Hayden
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MGI ID: |
MGI:2179728 |
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Synonyms: |
Hap1- |
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Gene:
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Hap1
Location:
Chr11:100347327-100356128 bp, - strand
Genetic Position: Chr11,
63.47 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76174
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: A PGK-neo derived cassette replaced most of exon 1 and intron 1 (downstream of the ATG start codon) via homologous recombination. Western blot of extracts from brain of homozygous mutant animals verified the absence of protein product. (J:76174)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hap1 Mutation:
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35 strains or lines available |
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| References |
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Original: |
J:76174
Chan EY et al.,
"Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior."
Hum Mol Genet 2002 Apr 15;11(8):945-59
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All: |
2 reference(s)
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Analysis Tools
