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| Nomenclature |
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Symbol:
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Tnfsf9tm1Thw
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Name:
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tumor necrosis factor (ligand) superfamily, member 9;
targeted mutation 1, Tania H Watts
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MGI ID: |
MGI:2179297 |
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Synonyms: |
4-1BBL-, 41BBL KO, CD137L- |
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Gene:
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Tnfsf9
Location:
Chr17:57105385-57107757 bp, + strand
Genetic Position: Chr17,
29.67 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76373
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette at nucleotide 52 via homologous recombination. Activated lymph node cells from homozygous mutant animals did not contain protein product as assayed by flow cytometry. (J:76373)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tnfsf9 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:76373
DeBenedette MA et al.,
"Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus."
J Immunol 1999 Nov 1;163(9):4833-41
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All: |
19 reference(s)
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Analysis Tools
