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| Nomenclature |
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Symbol:
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Tff3tm1Dkpy
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Name:
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trefoil factor 3, intestinal;
targeted mutation 1, Daniel K Podolsky
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MGI ID: |
MGI:2179219 |
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Synonyms: |
Itf- |
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Gene:
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Tff3
Location:
Chr17:31125306-31129646 bp, - strand
Genetic Position: Chr17,
15.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35882
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2 of this gene was replaced with a neo cassette via homologous recombination resulting in the deletion of the trefoil domain. Absence of gene expression in the gastrointestinal tract of homozygous mutant animals was confirmed by Northern blot analysis and immunohistochemistry. (J:35882)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:35882
Mashimo H et al.,
"Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor [see comments]"
Science 1996 Oct 11;274(5285):262-5
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All: |
4 reference(s)
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Analysis Tools
