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| Nomenclature |
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Symbol:
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Slc6a6tm1Dhau
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Name:
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solute carrier family 6 (neurotransmitter transporter, taurine), member 6;
targeted mutation 1, Dieter Haussinger
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MGI ID: |
MGI:2179132 |
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Synonyms: |
taut- |
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Gene:
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Slc6a6
Location:
Chr6:91684067-91759063 bp, + strand
Genetic Position: Chr6,
40.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74276
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 of this gene was replaced with a neomycin resistance gene via homologous recombination, resulting in a truncated protein deleted for transmembrane domains 1-2 as well as a large portion of the extracellular region. Transcripts including exon 1 were not expressed in kidney and liver of homozygous mutant animals as assayed by Northern blot. (J:74276)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:74276
Heller-Stilb B et al.,
"Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice."
FASEB J 2002 Feb;16(2):231-3
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All: |
10 reference(s)
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Analysis Tools
