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| Nomenclature |
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Symbol:
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Ppm1dtm1Lad
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Name:
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protein phosphatase 1D magnesium-dependent, delta isoform;
targeted mutation 1, Lawrence A Donehower
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MGI ID: |
MGI:2179128 |
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Synonyms: |
Wip1-, WIP1- |
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Gene:
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Ppm1d
Location:
Chr11:85311244-85347066 bp, + strand
Genetic Position: Chr11,
51.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74284
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4 and 5 were replaced with a PGK-puro cassette via homologous recombination resulting in protein truncation. Northern blot analysis of tissues from homozygous mutant animals did not detect gene transcript although a transcript with deleted exons 4 and 5, presumed to be unstable, was detected by RT-PCR. Western blot of irradiated testes from homozygous mutants did not detect protein product. (J:74284)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ppm1d Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:74284
Choi J et al.,
"Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control."
Mol Cell Biol 2002 Feb;22(4):1094-105
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All: |
11 reference(s)
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Analysis Tools
