Tg(GFAP-cre)25Mes
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(GFAP-cre)25Mes
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Name:
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transgene insertion 25, Albee Messing
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MGI ID: |
MGI:2179048 |
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Synonyms: |
Gfa2-Cre, GFAP-Cre, GFAP-Cre-m, hGFAPcre, hGFAP-cre, hGFAP::Cre, Tg95.2, TgN25Mes, TgN(GFAPcre)25Mes |
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Transgene:
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Tg(GFAP-cre)25Mes
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. (J:72509)
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Recombinase activity
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Activity in:
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adipose tissue,
alimentary system,
branchial arches,
cardiovascular system,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
nervous system,
postnatal-other,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
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Not detected in:
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cavities & their linings,
limbs,
mesenchyme,
muscle
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Driver:
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GFAP
Summary of all recombinase alleles
driven by GFAP.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable.
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| References |
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Original: |
J:72509
Zhuo L et al.,
"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo."
Genesis 2001 Oct;31(2):85-94
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All: |
122 reference(s)
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Analysis Tools
