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| Nomenclature |
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Symbol:
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Mdktm1Tmu
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Name:
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midkine;
targeted mutation 1, Takashi Muramatsu
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MGI ID: |
MGI:2178959 |
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Synonyms: |
Mdk-, Mk- |
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Gene:
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Mdk
Location:
Chr2:91929805-91932297 bp, - strand
Genetic Position: Chr2,
50.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76278
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 220 bp containing part of exon 1, intron 1 and part of exon 2 was replaced with a neomycin selection cassette. Northern blot analysis on total kidney RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from adult kidney confirmed that no detectable protein was expressed from this allele. (J:76278)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:76278
Nakamura E et al.,
"Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour."
Genes Cells 1998 Dec;3(12):811-22
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All: |
24 reference(s)
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Analysis Tools
