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| Nomenclature |
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Symbol:
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Tlr2tm1Aki
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Name:
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toll-like receptor 2;
targeted mutation 1, Shizuo Akira
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MGI ID: |
MGI:2178675 |
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Synonyms: |
Tlr2-, TLR2KO, TLR2 KO |
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Gene:
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Tlr2
Location:
Chr3:83836272-83841608 bp, - strand
Genetic Position: Chr3,
37.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76115
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neo cassette replaces the part of the exon that encodes the transmembrane and the cytoplasmic domain of this single exon gene. The absence of transcript was confirmed by Northern analysis of peritonel macrophages. (J:76115, J:91950)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:76115
Takeuchi O et al.,
"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components."
Immunity 1999 Oct;11(4):443-51
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All: |
437 reference(s)
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Analysis Tools
