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| Nomenclature |
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Symbol:
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Ubr1tm1Avar
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Name:
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ubiquitin protein ligase E3 component n-recognin 1;
targeted mutation 1, Alexander Varshavsky
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MGI ID: |
MGI:2178612 |
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Synonyms: |
UBR1 - |
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Gene:
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Ubr1
Location:
Chr2:120860269-120970715 bp, - strand
Genetic Position: Chr2,
60.37 cM
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Abnormal development of the central nervous system in Ubr1tm1Avar/Ubr1tm1Avar Ubr2tm1Ytkw/Ubr2tm1Ytkw embryos
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72859
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4 through 6 were replaced by a neo cassette. This coding sequence in this region is highly conserved between S.cerevisiae and mouse, and includes amino acids found to be essential for the type 1 and type 2 substrate binding site. (J:72859)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ubr1 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:72859
Kwon YT et al.,
"Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3alpha) of the N-End Rule Pathway."
Mol Cell Biol 2001 Dec;21(23):8007-21
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All: |
5 reference(s)
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Analysis Tools
