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| Nomenclature |
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Symbol:
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Dll3tm1Rbe
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Name:
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delta-like 3 (Drosophila);
targeted mutation 1, Rosa Beddington
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MGI ID: |
MGI:2178443 |
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Synonyms: |
Dll3neo |
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Gene:
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Dll3
Location:
Chr7:28293553-28302238 bp, - strand
Genetic Position: Chr7,
16.67 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75954
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Parent Cell Line:
| CGR8 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 5.4 kb of genomic sequence, including amino acids G135-S556 containing the DSL (Notch binding domain), all EGF repreats and the transmembrane domain was replaced with a PGK-neo cassette. (J:75954)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:75954
Dunwoodie SL et al.,
"Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm."
Development 2002 Apr;129(7):1795-806
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All: |
5 reference(s)
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Analysis Tools
