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| Nomenclature |
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Symbol:
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Serpinc1tm1Sai
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Name:
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serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1;
targeted mutation 1, Hidehiko Saito
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MGI ID: |
MGI:2178128 |
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Synonyms: |
AT-, ATIII- |
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Gene:
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Serpinc1
Location:
Chr1:160978606-161003010 bp, + strand
Genetic Position: Chr1,
69.75 cM
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Subcutaneous hemorrhage in Serpinc1tm1Sai/Serpinc1tm1Sai mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65092
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced exon 2 and flanking intronic sequences. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele, and western blot analysis on liver lysates confirmed that no protein was expressed from this allele. (J:65092)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Serpinc1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:65092
Ishiguro K et al.,
"Complete antithrombin deficiency in mice results in embryonic lethality"
J Clin Invest 2000 Oct;106(7):873-8
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All: |
3 reference(s)
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Analysis Tools
