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| Nomenclature |
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Symbol:
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Tcf3tm1Cmu
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Name:
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transcription factor 3;
targeted mutation 1, Cornelis Murre
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MGI ID: |
MGI:2178119 |
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Synonyms: |
E2A- |
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Gene:
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Tcf3
Location:
Chr10:80409514-80433647 bp, - strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67011
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a neomycin resistance cassette into the E12-specific exon disrupted the gene. RT-PCR studies of fetal liver and of lung from 5 week old mice detected trace amounts of E47-specific transcript in homozygous mutant mice. The authors predict that both gene products, E12 and E47, are inactivated in this allele. (J:67011)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tcf3 Mutation:
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18 strains or lines available |
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Notes |
ES cell line = either E14 or E14-derived.
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| References |
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Original: |
J:67011
Bain G et al.,
"E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements."
Cell 1994 Dec 2;79(5):885-92
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All: |
16 reference(s)
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Analysis Tools
