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| Nomenclature |
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Symbol:
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Krt8tm1Rgo
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Name:
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keratin 8;
targeted mutation 1, Robert G Oshima
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MGI ID: |
MGI:2178042 |
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Synonyms: |
K8-, mK8 - |
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Gene:
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Krt8
Location:
Chr15:101996711-102004342 bp, - strand
Genetic Position: Chr15,
57.2 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:12899
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a DNA segment containing most of the first exon including the translation initiation codon. Northern blot analysis on RNA isolated from gut, liver, kidney and spleen demonstrated that an aberrant transcript was made in gut, but no transcript was detectable elsewhere. Immunohistochemistry on sections of intestine of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:12899)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:12899
Baribault H et al.,
"Mid-gestational lethality in mice lacking keratin 8."
Genes Dev 1993 Jul;7(7A):1191-202
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All: |
21 reference(s)
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Analysis Tools
