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| Nomenclature |
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Symbol:
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Pin1tm1Tuc
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Name:
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protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1;
targeted mutation 1, Takafumi Uchida
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MGI ID: |
MGI:2177943 |
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Synonyms: |
Pin1- |
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Gene:
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Pin1
Location:
Chr9:20652130-20666584 bp, + strand
Genetic Position: Chr9,
7.6 cM
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Reduced body weight and testicular atrophy in Pin1tm1Tuc/Pin1tm1Tuc mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58734
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced exons 1-4, which contain the entire coding sequence of the gene. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:58734)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pin1 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:58734
Fujimori F et al.,
"Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest."
Biochem Biophys Res Commun 1999 Nov 30;265(3):658-63
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All: |
32 reference(s)
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Analysis Tools
