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| Nomenclature |
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Symbol:
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Lmnatm1Stw
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Name:
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lamin A;
targeted mutation 1, Colin L Stewart
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MGI ID: |
MGI:2177930 |
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Synonyms: |
Lmna- |
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Gene:
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Lmna
Location:
Chr3:88481148-88509956 bp, - strand
Genetic Position: Chr3,
38.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58702
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced a genomic segment containing exons 8-10. Western blot analysis on extracts of both embryonic fibroblasts and liver nuclear membranes from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:58702)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:58702
Sullivan T et al.,
"Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy."
J Cell Biol 1999 Nov 29;147(5):913-20
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All: |
31 reference(s)
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Analysis Tools
