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| Nomenclature |
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Symbol:
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Engtm1Mle
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Name:
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endoglin;
targeted mutation 1, Michelle Letarte
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MGI ID: |
MGI:2177824 |
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Synonyms: |
End -, Eng- |
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Gene:
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Eng
Location:
Chr2:32646595-32682658 bp, + strand
Genetic Position: Chr2,
22.09 cM
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Arrest in development in Engtm1Mle/Engtm1Mle embryos
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58502
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A lacZ gene and neomycin resistance cassette replaced exon 1. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable Eng transcript was produced. However, a beta-galactosidase protein was produced from this allele under the control of the endogenous promoter. (J:58502)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Eng Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:58502
Bourdeau A et al.,
"A murine model of hereditary hemorrhagic telangiectasia [see comments]"
J Clin Invest 1999 Nov;104(10):1343-51
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All: |
19 reference(s)
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Analysis Tools
