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| Nomenclature |
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Symbol:
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Liftm1Stw
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Name:
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leukemia inhibitory factor;
targeted mutation 1, Colin L Stewart
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MGI ID: |
MGI:2177780 |
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Synonyms: |
L-, Lif-, LIFKO |
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Gene:
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Lif
Location:
Chr11:4257557-4272514 bp, + strand
Genetic Position: Chr11,
2.94 cM, cytoband A1-A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35071
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance gene was inserted into exon 3. Northern blot analysis on embryonic fibroblasts isolated from homozygous embryos demonstrated that no detectable transcript was produced from this allele, and cell growth assays confirmed that no functional protein was expressed from this allele. (J:35071)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:35071
Stewart CL et al.,
"Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor [see comments]"
Nature 1992 Sep 3;359(6390):76-9
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All: |
25 reference(s)
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Analysis Tools
