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| Nomenclature |
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Symbol:
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Htttm2Szi
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Name:
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huntingtin;
targeted mutation 2, Scott Zeitlin
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MGI ID: |
MGI:2177755 |
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Synonyms: |
Hdhflox |
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Gene:
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Htt
Location:
Chr5:34761740-34912534 bp, + strand
Genetic Position: Chr5,
17.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65520
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette followed by a loxP site was inserted 5' to exon 1 and a single loxP site was inserted 3' to exon 1. (J:65520)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Htt Mutation:
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40 strains or lines available |
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| References |
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Original: |
J:65520
Dragatsis I et al.,
"Inactivation of hdh in the brain and testis results in progressive neurodegeneration and sterility in mice"
Nat Genet 2000 Nov;26(3):300-6
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All: |
9 reference(s)
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Analysis Tools
