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| Nomenclature |
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Symbol:
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Gcktm1.1Mgn
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Name:
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glucokinase;
targeted mutation 1.1, Mark A Magnuson
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MGI ID: |
MGI:2177709 |
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Synonyms: |
gklox |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51826
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: This allele is a derivative of Gcktm1Mgn in which the loxP flanked neomycin selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. (J:51826)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:51826
Postic C et al.,
"Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase."
J Biol Chem 1999 Jan 1;274(1):305-15
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All: |
4 reference(s)
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Analysis Tools
