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| Nomenclature |
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Symbol:
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Gcktm1Tka
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Name:
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glucokinase;
targeted mutation 1, Takashi Kadowaki
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MGI ID: |
MGI:2177703 |
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Synonyms: |
GK deficient |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:30334
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Parent Cell Line:
| A3-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 1beta, which contains the promoter for the pancreatic-specific isoform of the gene. Glucose phosphorylation assays on samples derived from pancreatic islets and liver tissue of homozygous mice confirmed that no functional protein was expressed in the pancreas, but liver expression was unaffected. (J:30334)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gck Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:30334
Terauchi Y et al.,
"Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose."
J Biol Chem 1995 Dec 22;270(51):30253-6
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All: |
12 reference(s)
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Analysis Tools
