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| Nomenclature |
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Symbol:
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Foxa2tm1Khk
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Name:
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forkhead box A2;
targeted mutation 1, Klaus H Kaestner
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MGI ID: |
MGI:2177337 |
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Synonyms: |
Foxa2flox, Foxa2loxP, HNF3betaflox |
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Gene:
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Foxa2
Location:
Chr2:148042877-148046969 bp, - strand
Genetic Position: Chr2,
73.38 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63039
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A single loxP site was inserted into intron 2 and a loxP flanked neomycin and thymidine kinase selection cassette was inserted into intron 3. The selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice, leaving exon 2 flanked by loxP sites in the final allele. (J:63039)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Foxa2 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:63039
Sund NJ et al.,
"Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte."
Mol Cell Biol 2000 Jul;20(14):5175-83
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All: |
29 reference(s)
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Analysis Tools
