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| Nomenclature |
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Symbol:
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Brca2tm2Arge
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Name:
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breast cancer 2;
targeted mutation 2, Argiris Efstratiadis
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MGI ID: |
MGI:2177211 |
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Synonyms: |
Brca2flox |
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Gene:
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Brca2
Location:
Chr5:150522630-150569746 bp, + strand
Genetic Position: Chr5,
89.52 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70564
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site followed by a neomycin selection cassette was inserted 5' to exon 3 and a single loxP site was inserted 3' to exon 4. (J:70564)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Brca2 Mutation:
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32 strains or lines available |
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| References |
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Original: |
J:70564
Ludwig T et al.,
"Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice."
Oncogene 2001 Jul 5;20(30):3937-48
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All: |
1 reference(s)
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Analysis Tools
