Tg(Nes-cre)1Atp
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Nes-cre)1Atp
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Name:
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transgene insertion 1, Andreas Trumpp
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MGI ID: |
MGI:2176835 |
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Synonyms: |
Nes-Cre1, Nestincre, Nestin-Cre, Tg(Nes-cre)1Mrt |
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Transgene:
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Tg(Nes-cre)1Atp
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The 5' region of the rat nestin gene was placed upstream of an NLS-Cre-pA and the rat nestin intron 2. This line carried a single or low copy transgene. The absence of transcript expression was confirmed by RT-PCR on endoneurial extracts. This promoter is active by E9 in the CNS progenitor cells. Transgene is paternally imprinted, thus brain-specific recombination is only 30% when allele is maternally inherited, compared to ~95% with paternal transmission (J:75417, J:121563). (J:58999, J:111945)
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Recombinase activity
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Activity in:
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alimentary system,
branchial arches,
cardiovascular system,
cavities & their linings,
embryo-other,
extraembryonic component,
head,
hemolymphoid system,
integumental system,
liver & biliary system,
mesenchyme,
nervous system,
renal & urinary system,
respiratory system,
sensory organs,
skeletal system
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Driver:
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Nes
Summary of all recombinase alleles
driven by Nes.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:58999
Trumpp A et al.,
"Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch."
Genes Dev 1999 Dec 1;13(23):3136-48
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All: |
50 reference(s)
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Analysis Tools
