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| Nomenclature |
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Symbol:
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Leprtm1.1Rck
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Name:
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leptin receptor;
targeted mutation 1.1, Jeffrey M Friedman
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MGI ID: |
MGI:2176775 |
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Synonyms: |
ObRdelta |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72241
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is a derivative of Leprtm1.1Rck in which exon 1 and flanking sequences were deleted in the germline by crossing mice carrying this allele to mice carrying Tg(EIIa-Cre)1Lmgd. (J:72241)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lepr Mutation:
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27 strains or lines available |
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| References |
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Original: |
J:72241
Cohen P et al.,
"Selective deletion of leptin receptor in neurons leads to obesity."
J Clin Invest 2001 Oct;108(8):1113-21
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All: |
1 reference(s)
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Analysis Tools
