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| Nomenclature |
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Symbol:
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Leprtm1Rck
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Name:
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leptin receptor;
targeted mutation 1, Jeffrey M Friedman
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MGI ID: |
MGI:2176774 |
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Synonyms: |
ObRflox |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72241
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A single loxP site was inserted 5' to exon 1 and a loxP-flanked neomycin and thymidine kinase selection cassette was inserted 3' to exon 1. The selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. leaving a single loxP site 3' to exon 1 in the final allele. (J:72241)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:72241
Cohen P et al.,
"Selective deletion of leptin receptor in neurons leads to obesity."
J Clin Invest 2001 Oct;108(8):1113-21
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All: |
6 reference(s)
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Analysis Tools
