|
|
| Nomenclature |
|
Symbol:
|
Casrtm1Ces
|
|
Name:
|
calcium-sensing receptor;
targeted mutation 1, Christine Seidman
|
|
MGI ID: |
MGI:2176758 |
|
Synonyms: |
CaR-, Casr- |
|
Gene:
|
Casr
Location:
Chr16:36493696-36562141 bp, - strand
Genetic Position: Chr16,
25.57 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:29900
|
|
Parent Cell Line:
| C1 (ES Cell) |
|
Strain of Origin:
|
129X1/SvJ
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A neomycin resistance gene was inserted into exon 4. Western blot analysis on kidney protein membrane extracts from homozygous mice confirmed that no detectable protein is expressed from this allele. RT-PCR analysis of chondrocytes from homozygous mice detected the presence of a smaller transcript lacking exon 5. In addition protein expression is detected in the growth plates of homozygous mice. (J:29900, J:129678)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Casr Mutation:
|
4 strains or lines available |
|
| References |
|
Original: |
J:29900
Ho C et al.,
"A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism [see comments]"
Nat Genet 1995 Dec;11(4):389-94
|
|
All: |
26 reference(s)
|
|
Analysis Tools
