|
|
| Nomenclature |
|
Symbol:
|
Bdnftm3Jae
|
|
Name:
|
brain derived neurotrophic factor;
targeted mutation 3, Rudolf Jaenisch
|
|
MGI ID: |
MGI:2176750 |
|
Synonyms: |
Bdnf2, Bdnf2L, Bdnf2lox, Bdnftm2Jae |
|
Gene:
|
Bdnf
Location:
Chr2:109674700-109727007 bp, + strand
Genetic Position: Chr2,
56.63 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:71969
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A single loxP site was inserted 5' to the only coding exon, and a loxP-flanked hygromycin resistance cassette was inserted 3' to the exon. The hygromycin selection cassette was removed in ES cells by transient Cre expression leaving a single loxP site prior to the production of chimeric mice. (J:71969)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:71969
Rios M et al.,
"Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity."
Mol Endocrinol 2001 Oct;15(10):1748-57
|
|
All: |
34 reference(s)
|
|
Analysis Tools
